少喝点就没事?酒精对心脏危害有多大,这项研究告诉你

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俗话说,“小酌怡情,大饮伤身”。很多人虽然知道酒精损害健康,但往往以为“适量”喝一点没什么问题。然而越来越多的科学研究告诉我们,喝酒并没有一个“安全”的界限,即使是喝得不多也会造成健康损害。近期,根据欧洲心脏病学会(European Society of Cardiology)“心力衰竭”主题年会上新发表的一项研究,酒精对心脏的风险可能比过去以为的更大。

尽管世界各地对饮酒量的限制并不一致,然而低于某些地区所谓的“推荐量”或“安全量”水平,仍然可以发现饮酒与心力衰竭的发展密切相关。

少喝点就没事?酒精对心脏危害有多大,这项研究告诉你

研究人员重点关注了一种被称为“酒精性心肌病”的心力衰竭。这种疾病的罪魁祸首就是酒精,由于酒精以及酒精在人体内的代谢产物——乙醛对心肌有直接毒害,日结月累,心肌会变得像被牵扯过度的橡皮筋,弹性变差,无法有效地泵送血液。

酒精性心肌病通常被认为是长期大量饮酒导致的结果。所谓的“大量”,以爱尔兰为例,定义为每周纯酒精摄入量女性超过110克、男性超过170克。但在这项研究中,爱尔兰都柏林圣文森特大学医院的研究人员发现,实际上低于这个饮酒量仍然有危险

研究人员分析了有心力衰竭高危风险(例如高血压、糖尿病、肥胖等)或是处于心力衰竭前期(有前述危险因素且心脏出现异常,但还未发展出症状)的700多名受试者,通过超声心动图测量了他们的心脏功能,并进行了平均5.4年时间的随访,调查了这些受试者心脏健康与酒精摄入之间的关系。

根据每周纯酒精摄入量,研究人员将受试者分为4组,分别是:

不饮酒;

少量饮酒(少于70克,相当于最多一瓶750毫升12.5%葡萄酒,或三罐半、每罐500毫升的4.5%啤酒);

中度饮酒(70克~140克,相当于最多两瓶12.5%葡萄酒,或七罐4.5%啤酒);

大量饮酒(140克以上,相当于两瓶以上12.5%葡萄酒或七罐以上4.5%啤酒)。

分析结果显示,心力衰竭前期的受试者中,与不饮酒相比,中度饮酒和大量饮酒组的心脏健康恶化风险增加4.5倍,更有可能进展为有症状的心力衰竭。“我们的研究表明,欧洲人每周饮酒超过 70 克与心力衰竭前期的恶化或进展为症状性心力衰竭有关。研究人员强调。“这一结果意味着,我们发现的安全量只有爱尔兰建议的每周酒精摄入量的一半不到。”

在高危风险受试者中,中度饮酒或大量饮酒与是否进展为心力衰竭前期或有症状的心力衰竭之间没有关系。此外,研究结果没有发现少量饮酒有任何保护作用

值得一提的是,这项研究主要调查了饮酒量较大的欧洲人,而一些来自亚洲人群的证据表明,相比欧洲人群,更低的酒精摄入量就可能对亚洲人造成心肌损伤。由于遗传基因的差别,很多亚洲人无法顺利代谢酒精,导致酒精及其代谢产物在体内造成的损伤更多,换句话说,亚洲人在酒精面前的抵抗力更弱。

也许有的人是为了开心而喝酒,然而种种研究证据告诉我们,酒精却会造成真正的“伤心”。“这项研究增加了大量证据表明应当更谨慎地看待喝酒,”研究作者Bethany Wong博士说。“为了尽量减少酒精对心脏造成伤害的风险,能不喝酒就不要开始喝酒,喝酒的人最好把每周饮酒量限制在一瓶葡萄酒或者三罐半啤酒以下

参考资料:

[1] Alcohol may be more risky to the heart than previously thought。 Retrieved May 31, 2022 from https://www.eurekalert.org/news-releases/953314

[2] Bethany Wong (2022) Moderate alcohol consumption is associated with progression of left ventricular dysfunction in a European stage B heart failure population。

本文来自药明康德内容微信团队

Although restrictions on alcohol consumption vary around the world, below the so-called "recommended" or "safe" levels in some areas, alcohol consumption can still be found to be closely related to the development of heart failure.

The researchers focused on a species called "Alcoholic cardiomyopathy”的心力衰竭.这种疾病的罪魁祸首就是酒精,由于酒精以及酒精在人体内的代谢产物——乙醛对心肌有直接毒害,日结月累,心肌会变得像被牵扯过度的橡皮筋,弹性变差,无法有效地泵送血液.

Alcoholic cardiomyopathy is usually thought to be the result of long-term heavy drinking.. The so-called "large amount", in Ireland, for example, is defined as more than 110 grams of pure alcohol per week for women and 170 grams for men. But in this study, researchers at St. Vincent University Hospital in Dublin, Ireland, foundActuallyIt is still dangerous to drink below this amount..

The researchers analyzed more than 700 subjects who were at high risk of heart failure (such as high blood pressure, diabetes, obesity, etc.) or in the early stages of heart failure (with these risk factors and heart abnormalities, but had not yet developed symptoms). Their heart function was measured by echocardiography and followed up for an average of 5.4 years to investigate the relationship between heart health and alcohol intake.

According toWeekly pure alcohol intakeThe researchers divided the subjects into four groups:

Don't drink.

Drink a small amount of alcohol (less than 70 grams, equivalent to up to a bottle of 750 ml 12.5% wine, or three and a half cans of 4.5% beer with 500 ml each)

Moderate alcohol consumption (70g ~ 140g, equivalent to up to two bottles of 12.5% wine, or seven cans of 4.5% beer)

Drink heavily (more than 140 grams, equivalent to more than two bottles of 12.5% wine or more than seven cans of 4.5% beer).

The analysis results show thatAmong subjects in the early stages of heart failure, moderate and heavy drinking groups had a 4.5-fold increased risk of deteriorating heart health compared with non-drinking groups, and were more likely to progress to symptomatic heart failure.. "our research shows that Europeans drinking more than 70 grams a week is associated with the deterioration or progression of symptomatic heart failure in the early stages of heart failure. The researchers stressed. "this result means thatThe safe amount we found was less than half of Ireland's recommended weekly alcohol intake."

Among high-risk subjects, moderate or heavy drinking was not associated with progression to pre-heart failure or symptomatic heart failure. In additionThe results of the study did not find that a small amount of alcohol consumption had any protective effect..

It is worth mentioning that the study focused on heavy drinkers in Europe, while some evidence from Asian populations suggests that lower alcohol intake may cause myocardial damage in Asians than in Europeans. Due to genetic differences, many Asians are unable to metabolize alcohol smoothly, causing more damage to alcohol and its metabolites in the body. in other words, Asians are less resistant to alcohol.

Maybe some people drink to be happy, but all kinds of research evidence tells us that alcohol can cause real "sadness".. "this study adds a lot of evidence that drinking should be treated more cautiously," said study author Dr. Bethany Wong. "in order to minimize the risk of heart damage caused by alcoholDon't start drinking if you can't drink. Drinkers had better limit their weekly consumption to less than one bottle of wine or three and a half cans of beer..

Reference:

[1] Alcohol may be more risky to the heart than previously thought . Retrieved May 31, 2022 from https://www.eurekalert.org/news-releases/953314

Bethany Wong (2022) Moderate alcohol consumption is associated with progression of left ventricular dysfunction in an European stage B heart failure population.

This article is from the Wechat team of Yao Ming Kant content.

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